Molecular Imaging

Topgene Biotechnology’s Molecular Imaging Center is dedicated to non-human primate molecular imaging, drug screening and preclinical evaluation, and CRO services. The molecular imaging center provides molecular imaging drug research and development outsourcing, drug radiolabeling synthesis, new PET imaging agent research, tumor therapy and targeted therapy technology services. It is committed to PET molecular imaging, which combines the molecular imaging technology of functional and structural imaging. It applies imaging means to display specific molecules at the tissue level, cell and subcellular level to reflect the changes at the molecular level in the living state, and conduct qualitative and quantitative drug research of the imaging of its biological behavior.


1. The future trends of non-clinical drug screening and drug evaluation.

2. Radioisotope labeled drug molecules PET/CT, PET/MRI imaging technology.

3. Non human primate resources + monkey disease model.


11C automatic labeling system for reflective drugs


1. Radiolabeling synthesis of molecular imaging drug research and development outsourcing  

2. Tumor therapy targeted therapy technology services

3. Research of new PET imaging agent

4. In vivo molecular imaging technology, dynamic, quantitative and accurate acquisition of pharmacokinetic (PK) and pharmacodynamic (PD) data in small animals

Imaging Solution

Aquisition of animal model imaging

a. MicroPET (positron emission tomography)

b. MicroSPECT (single photon emission computed tomography)


Radiochemical and pharmaceutical non clinical and clinical imaging research services

c. Positron (PET) tracer for non-human primates (1) macromolecule: 124I, 89Zr, 64Cu (2) small molecule: 68Ga, 15F

d. Chemical labeling: organic and radiochemical labeling of any drug or tracer


It establishes a world-class image data analysis platform

It can provide data collection and analysis in real time and simplify the work flow through specific application tools.

The main functions include: applicable to brain spectra of rodents and non-human primates, and receptor occupancy studies

PET clinical study

e. Clinical 0 phase study: also known as microdose study.

f. Especially for the candidate drugs of nervous system CNS, micro administration is very important to study the blood-brain barrier


Four Fields in Application

Drug safety evaluation

 to detect the toxicity of drugs to the body

Biological validation

 reflects the tissue distribution of drugs


to obtain constants of pharmacokinetic

Pharmacological validation and pharmacodynamic evaluation

It shows the extent to which the receptor is occupied by the drug, the affinity and biological activity of the reaction drug to the receptor