Topgene Biotechnology’s Molecular Imaging Center is dedicated to non-human primate molecular imaging, drug screening and preclinical evaluation, and CRO services. The molecular imaging center provides molecular imaging drug research and development outsourcing, drug radiolabeling synthesis, new PET imaging agent research, tumor therapy and targeted therapy technology services. It is committed to PET molecular imaging, which combines the molecular imaging technology of functional and structural imaging. It applies imaging means to display specific molecules at the tissue level, cell and subcellular level to reflect the changes at the molecular level in the living state, and conduct qualitative and quantitative drug research of the imaging of its biological behavior.
Highlights
1. The future trends of non-clinical drug screening and drug evaluation.
2. Radioisotope labeled drug molecules PET/CT, PET/MRI imaging technology.
3. Non human primate resources + monkey disease model.
Patent
11C automatic labeling system for reflective drugs
1. Radiolabeling synthesis of molecular imaging drug research and development outsourcing
2. Tumor therapy targeted therapy technology services
3. Research of new PET imaging agent
4. In vivo molecular imaging technology, dynamic, quantitative and accurate acquisition of pharmacokinetic (PK) and pharmacodynamic (PD) data in small animals
a. MicroPET (positron emission tomography)
b. MicroSPECT (single photon emission computed tomography)
c. Positron (PET) tracer for non-human primates (1) macromolecule: 124I, 89Zr, 64Cu (2) small molecule: 68Ga, 15F
d. Chemical labeling: organic and radiochemical labeling of any drug or tracer
It can provide data collection and analysis in real time and simplify the work flow through specific application tools.
The main functions include: applicable to brain spectra of rodents and non-human primates, and receptor occupancy studies
e. Clinical 0 phase study: also known as microdose study.
f. Especially for the candidate drugs of nervous system CNS, micro administration is very important to study the blood-brain barrier
Four Fields in Application
to detect the toxicity of drugs to the body
reflects the tissue distribution of drugs
to obtain constants of pharmacokinetic
It shows the extent to which the receptor is occupied by the drug, the affinity and biological activity of the reaction drug to the receptor
