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Macaca fascicularis model of Alzheimer's disease (AD)
1. The increased level in Aβ42，Aβ42/Aβ40 and neurofilament light (NfL) in cerebrospinal fluid (CSF) and the plasma detected by ELISA and MSD.
2. The β-sheets enriched in the prefrontal cortex imaged by ThioS staining.
3. The Aβ positive staining in prefrontal cortex (PFC) detected by 4G8 and 6E10 immunohistochemical staining.
4. Astrocytes and microglia activation in the prefrontal cortex detected by immunohistochemistry.
5. The increased level of phosphorylated Tau protein in the frontal lobe and hippocampus extracts detected by ELISA, Western blotting and immunohistochemistry.
6. Accumulation of Amyloid beta (Aβ) and Tau in the brain detected positron emission tomography (PET)and magnetic resonance imaging (MRI).
The increased Aβ (A) and Tau (B) accumulation in the model monkey brain detected by PET/MR imaging.
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