Pharmacodynamic Evaluation-Hubei Topgene Biotechnology Co., Ltd.

Pharmacodynamic Evaluation

The Non-clinical Pharmacology and Pharmacokinetics Services Department is equipped with a highly specialized team with experts in pharmacology, molecular pharmacology, neuropharmacology, cell biology, molecular biology, immunology, and veterinary medicine. Our services encompass a wide range of areas including gene therapy drugs, antibody drugs, cytokine drugs and protein drugs, as well as large-scale in vitro and in vivo screening of chemical drugs, suitable for preclinical efficacy evaluation studies applicable for domestic and international declarations. With extensive experience in drug screening and a comprehensive set of advanced screening technologies, we support our clients in drug development projects effectively. Our aim is to enhance the success rate of new drug development, reduce development costs, and shorten the development time.

Routes of Administration

Routes
Rat/Mouse
Guinea-pig
Rabbit
Dog/Pig
NHP
Intracranial injection
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Intragastric administration
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Oral administration
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Oral mucosal administration
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Aerosol inhalation
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Intranasal administration
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Spinal cavity administration
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Vitreous cavity administration
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Intrathoracic injection
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Intraperitoneal injection
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Subcutaneous injection
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Intracutaneous injection
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Intramuscular injection
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Transdermal administration
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Intravenous injection
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Rectal
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Intravaginal administration
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Intra-articular injection
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Specialized Services ● Modeling Technology

Neurological Disorders
① Monkey models for Alzheimer's disease and Parkinson's disease.
② Mouse and rat models for Alzheimer's disease, Parkinson's disease, pain, cerebral hemorrhage; mouse models for depression, autism; rat models for trigeminal neuralgia, selective occlusion of the middle cerebral artery, spinal cord injury.
Metabolic Disorders
① Monkey models for non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, liver fibrosis, obesity, hyperlipidemia, diabetes; monkey glucose tolerance test.
② Mouse and rat models for obesity, diabetes, non-alcoholic fatty liver disease, hyperlipidemia, hyperuricemia, acute gout, sepsis, cholestasis.
Cardiovascular Diseases
Mouse and rat models for aortic dissection, myocardial ischemia, reperfusion injury, stroke, hypertension.
Disorders Related to Urinary System
Mouse and rat models for renal fibrosis, renal failure.
Disorders Related to Motor System
Mouse and rat models for arthritis, osteoporosis.
Malignant Tumors
Mouse models for liver in situ tumors, subcutaneous tumor transplantation in nude mice.
Models Under Development
Monkey models for pulmonary fibrosis, renal fibrosis, depression, liver in situ tumors, heart failure, myocardial hypertrophy, etc.

Sample Collection Techniques

Blood Samples
Blood collection from a caudal vein, orbital venous plexus, submandibular gland vein, jugular vein (artery), femoral artery (vein), auricular limbus vein, forelimb head vein, hind limb small vein, etc.
Urinary Samples
Urine collection by metabolic cage, catheterization, ureteral intubation, and bladder compression
Fecal Samples
Feces collection in metabolic cage
Cerebrospinal Fluid Samples
Cerebrospinal fluid collection by lumbar puncture
Liver Samples
Liver collection by liver puncture
Ascites Samples
Ascites collection by abdominal puncture
Bile Samples
Bile collection by bile duct intubation

Service Capabilities