Non-human primates (NHPs), such as cynomolgus monkey, are important models for hemophilia research, contributing to a deeper understanding of the mechanism of the disease, evaluating the effectiveness of treatments, and promoting the translation of scientific research results into the clinic. The use of this model will further promote the development of the hemophilia field and bring new breakthroughs and hopes for the treatment and management of the disease.

By injecting Anti-Factor VIII into cynomolgus monkey, we successfully constructed A cynomolgus monkey model of acute hemophilia type A, and verified the reliability of the model.

1. The significantly prolonged APTT time up to four times longer than before modeling.

                                                Figure 1. Change in APTT after modeling.

        2. The significantly increased area of subcutaneous bruising after modeling.

                                              Figure 2. Change in bruised area after modeling.

          3.The significantly reduced hemoglobin levels after modeling.

                                                 Figure 3. Change of hemoglobin level after modeling.