Cellular Assay Systems:Comprehensive cell biology experiments, including primary cell culture and immortalized line manipulation.
Target Engagement & Confirmation: Molecular verification of target binding and downstream signaling modulation to confirm therapeutic mechanism of action (MoA).
Small Molecule Bioanalytics (PK/PD)
Pharmacokinetic (PK) Analysis:Quantitative detection and kinetic modeling of small molecule candidates in diverse biological matrices.
Metabolite Profiling:Identification and characterization of metabolic pathways, including structural elucidation of primary and secondary metabolites.
Biologics and Advanced Therapeutics (Large Molecules)
Antibody-Based Therapeutics:Precision analysis of monoclonal antibodies and complex , Antibody-Drug Conjugates (ADCs).
Nucleic Acid & Peptide Drugs: Quantitative assessment of antisense oligonucleotides (ASOs), siRNAs, and Peptide-Drug Conjugates (PDCs).
Biomarker Discovery:Development and validation of assays for clinical and preclinical biomarkers to monitor therapeutic response.
Immunogenicity & Safety: Comprehensive assessment of Anti-Drug Antibodies (ADA), including titer determination and neutralizing antibody (NAb) assays.
Vaccines & CGT Products:Potency testing and immunogenicity profiling for vaccines, as well as specialized detection for Cell and Gene Therapy (CGT) products
Intracellular Cytokine Staining (ICS) by Flow Cytometry:Multiparametric detection of cytokine production at the single-cell level following cellular stimulation, facilitating immune response profiling.
Intracellular & Nuclear Marker Detection:Advanced flow cytometry and imaging-based methods for precise quantification of cytoplasmic and nuclear targets, supporting mechanistic studies and biomarker analysis.
Bioanalysis
Biomarker analysis
siRNA platforms
Topgene Biotechnology
marketing@topgenebio.com
Contact Us
Thank you for your attention to Topgenebio. Please fill in the information below, and we will contact you as
soon as possible.