IgA Nephropathy
NHP Models of IgA Nephropathy (IgAN)
The combined use of BSA, LPS, and CCl₄ impairs the clearance of excess IgA from the blood and glomeruli. This leads to pathological changes characterized primarily by the deposition of IgA-dominant immune complexes in the mesangial region, along with mesangial cell proliferation and increased mesangial matrix.
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Figure 1. Immunohistochemistry (IHC) results of liver and kidney tissues. Increased IgA expression in the liver and deposition of IgA-antibody complexes and complement complexes near the glomeruli are observed in model animals (scale bar = 50 μm).
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